The single-use automatic top mixing system is suitable for liquid-liquid and solid-liquid mixing. It proves to be highly efficient and energy-saving. The ergonomic design makes it convenient and quick to use. The real time on-line monitoring function provides means for reliable process control. The modular design allows customization of different impellers, bags, and support containers. In addition, the automatic lifting system can be adjusted for different compounding volumes. This provides flexible solutions for many different biopharmaceutical process applications, including buffer preparation, mixing of intermediates, aseptic mixing of buffer, serum and reagents for cell culture media, and other solutions.